Noninvasive Diagnostic Monitor

This project is an Israeli medical device company specializes in infrared based technologies. The company's unique knowhow of the interface between harmless infrared light and the human tissue, combined with machine learning, enables the development of new diagnostic modalities. It is developing 4 modalities: A real time, noninvasive diagnostic monitor for determining levels of the widely used general anesthetic drug Propofol during anesthesia, a scanner for early detection of pressure injuries, a noninvasive diagnosing of middle ear infection syndrome and monitoring treatment, and a noninvasive real-time for diagnostic and defining dry eye syndrome.  

Market Background

The statistics (in Europe ) of Anesthesia demonstrates that: Over the age of 65 years, up to 1 year after general anesthesia , 1 : 10 will die from general anesthesia related side effects.Besides, there are following shortcomings of traditional Propofol Administration methods:

Bolus manual injection

Inaccurate drug dosing, physician dependent, produces severe side effects, longer recovery from anesthesia, longer hospitalization & post operation complications.

TCI syringe pumps

• Administration models do not follow different populations accurately enough (obese, children, aging population, cardiovascular problems)

• Diminished efficacy, undesired side effects in sick patients

In terms of pressure injuries, 2.5 million patients per year are effected with pressure injuries in the USA. Pressure injuries cost $9.1-$11.6 billion per year. Cost of individual patient care ranges from $20,900 to 151,700 per pressure injury. About 60,000 patients die as a direct result of a pressure injuries each year in the USA.

Project Introduction

Real time non-invasive monitoring of the anesthetic and sedative drug Propofol:

Propofol is the most commonly used drug for induction and maintenance of anesthesia and sedation. Propofol should be monitored for its real blood concentration to ensure optimal drug performance and to reduce side effects, morbidity and mortality associated with its use.

Currently, there is no real-time measurement of Propofol blood levels in patients under Propofol anesthesia or sedation. Using This project monitor could help non-anesthesiologist physician to administer Propofol for sedation in procedural interventions and save extra costs of up to US$ 1000 per procedure in the USA.

Status of product:

With Israel Ministry of Health and Local IRB approval, first set of human subjects was completed in a leading medical center in Israel. Initial results demonstrate the ability to follow Propofol blood concentration changes noninvasively, in real time and in a repeatable manner.

Early Detection of pressure injuries

This project is developing a handheld scanner to detect early subdermal physiological changes and prevent the appearance of life risking pressure injuries. A specially designed optic probe is placed for a few seconds on defined bony prominence points of the human body which identify typical biomarkers that appear under the skin in early stages of pressure injuries formation.

• Accurate pressure injuries documentation of each patient is electronically generated

• Accurate real time diagnosis is available for caregivers

• Treatment monitoring allows dramatic cost reduction

Middle ear infection

Middle ear infection, known as otitis media, is an inflammation of the middle ear with accumulation of fluid or pus (effusion) behind the eardrum (tympanic membrane). It is the commonest disease in babies and children.  This project develops a breakthrough light based technology for diagnosing, with no touch, middle ear infection and determine composition of the effusion within the middle ear, whether clear fluid or pus, in less than a second. The results can be displayed on an otoscope, help solving the clinical dilemmas regarding middle ear infection which otherwise requires a lengthy laboratory process. 

Dry eye syndrome

Dry eye syndrome, known as keratoconjunctivitis sicca. This project developed a breakthrough light based technology for diagnosing, with no touch, dry eye syndrome and defining the individual composition of the tear film and its stability, in just few seconds. To this end, This project measures tear evaporation time and tear film composition without touching the eye globe in a glimpse.

Team Member

Ronnie, B.SC M.BA CEO

Biochemical engineer from the Technion, Israeli institute of technology Experienced entrepreneur with turning good ideas into selling products in the medical device field and pharma . Experienced in medical devices development, market development and fund raising, Submitted 14 patents.


Mr. Cohen is an experienced engineer in the fields of wave propagation and IR Spectroscopy for medical applications and he is a co-author of 8 articles in scientific journals and in reports of worldwide conferences, 2 patents and 4 patents application in medical devices. Previously, Mr. cohen worked at a global Hi-Tech companies (Tokyo Electron , CISCO).

Dr. Dekel, Scientific Advisory

Dr.Dekel PhD E.E, . scientific expert. An electro optical engineer with an experience of about 25 years, specialized in the fields of mid IR optical waveguides of the planar and cylindrical types based on polycrystalline silver halide mixed crystals and IR Spectroscopic for medical applications

Project Need

This project is looking to raise $1.5 M in a first round of investment that will bring the company to run its planned activities:

• Continue large scale clinical validation of a Propofol monitoring device

• Develop disposables for the Propofol monitor and pressure injuries early detection scanner

• Submit the Propofol monitoring device to regulatory approvals (CE, FDA)

• Continue larger scale clinical trials in early detection of pressure injuries

• Submit the early detection of pressure injuries device to CE, FDA approval

• Continue BD with large strategic partners and get ready to the next fundraising round